Zeocin™ 1 g

Zeocin™ belongs to the structurally related group of bleomycin/phleomycin type antibiotics.

Zeocin™ belongs to the structurally related group of bleomycin/phleomycin type antibiotics. It is used as a selective agent in transformation experiments with mammalian cells, plant cells and yeast. The cytotoxic effect results from the ability to cause fragmentation of DNA. Zeocin™ binds to DNA throµgh its amino-terminal peptide, and the activated complex generates free radicals that are responsible for scission of the DNA chain. Zeocin™ is used as a selective agent for the incorporation of the Sh ble gene which encodes a 13,665 dalton protein. The encoded protein prevents damage of DNA by binding to Zeocin™, thus inhibiting the binding to DNA. Zeocin™ is a trademark of Cayla.