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rHu Activin A

5 g

Recombinant human human Activin A protein produced in Nicotiana benthamiana.

175,00 € (EUR)

plus 19% VAT and
shipping costs

Activins are homodimers or heterodimers of the various ? subunit isoforms, belonging to the TGF? family. Mature Activin A has two 116 amino acids residues ?A subunits (?A-?A). Activin exhibits a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins plays a key role in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells known to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells. As with other members of the super-family, Activins interact with two types of cell surface trans-membrane receptors (Types I and II) which have intrinsic serine/threonine kinase activities in their cytoplasmic domains, Activin type 1 receptors, ACVR1, ACVR1B, ACVR1C and Activin type 2 receptors, ACVR2A, ACVR2B. The biological activity of Activin A can be neutralized by inhibins and by the diffusible TGF-B antagonist, Follistatin. Amino acid sequence: HHHHHHGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS.

rHu Activin A 5 g - RF0009-5

rHu Activin A 5 g - RF0009-5

Productnumber: RF0009-5

Deutsch rHu Activin A 5 g
Antikrper & Zytokine

Application: postive controls, immunogens

Source: Nicotiana benthamiana

Technical Data: Purity: >97% (FPLC); p.I.: 7.27; MW=27.4 kDa (disulfide-linked homodimers of two A chains, each 116 amino acids); Endotoxin: < 0.04 EU/mg protein (LAL method); molecular formula: C600H911N173O174S13.

Shipping/Storing-Information: shipped at RT, stored at -20C

Documentation:


pdf rHu Activin A 5 g

Productdetails:


pdf rHu Activin A 5 g

Matchcode: activin