rHuBAFF 20 µg

Rec. human BLyS from E.Coli is a single, non-glycosylated polypeptide chain of 153 amino acids and a molecular mass of 17007 Dalton. Synonyms: BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B, B-cell Activating Factor.

Binds to tnfrsf13b/taci and tnfrsf17/bcma. tnfsf13/april binds to the same 2 receptors, together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. A third b-cell specific baff-receptor (baffr/br3) promotes the survival of mature b-cells and the b-cell response. B Lymphocyte Stimulator functions as a potent B-cell growth factor in costimulation assays. Administration of rec. human BAFF to mice disrupts splenic B-cell and T-cell zones and results in elevated levels of serum immunoglobulin. Rec. human BLyS from E.Coli is a single, non-glycosylated polypeptide chain of 153 amino acids and a molecular mass of 17007 Dalton. Synonyms: BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B, B-cell Activating Factor.