rHuIL-12 p40 His 1 mg

Recombinant Human Interleukin-12 p40 His Tag. Synonyms: NKSF2, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40), TSF, Edodekin-alpha, IL-12 p40, IL-12B, IL-12 subunit p40, NK cell stimulatory factor chain 2.

Rec. human Interleukin-12 p40 His produced in E.Coli is single, a non-glycosylated, polypeptide chain of 306 amino acids (fragment 23-328) with an amino-terminal hexahistidine tag. Active IL-12 is a p70 disulphide-linked dimer composed of p35 and p40 subunits. The protein is a pleiotropic cytokine produced primarily by antigen presenting cells and has multiple effects on T lymphocytes and natural killer cells in terms of stimulating cytotoxicity, proliferation, production of other cytokines and Th1 subset differentiation.