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rec. Human Stromal Cell-Derived Factor-1 alpha (rHuSDF-1a)

1 mg

Lyophilized from a concentrated (1 mg/mL) solution with no additives.

3147,43 € (EUR)

plus 19% VAT and
shipping costs

Recombinant Human IL-SDF-1a produced in E.Coli is a non-glycosylated, polypeptide chain of 68 amino acids and having a molecular mass of 8,008 Dalton. SDF-1 (stromal cell-derived factor-1) is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12). It is produced in two forms, SDF-1?/CXCL12a and SDF-1?/CXCL12b, by alternate splicing of the same gene. Chemokines are characterized by the presence of four conserved cysteines, which form two disulfide bonds. The CXCL12 proteins belong to the group of CXC chemokines, whose initial pair of cysteines are separated by one intervening amino acid. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development. During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow. Mice which were knocked-out for CXCL12 gene were lethal before the birth or within just 1 hour of life. As another role, CXCL12a alters also the electrophysiology of neurons. CXCL12 was shown to be expressend in many tissues in mice (including brain, thymus, heart, lung, liver, kidney, spleen and bone marrow). The receptor for this chemokine is CXCR4, which was previously called fusin. This CXCL12-CXCR4 interaction used to be considered exclusive (unlike for other chemokines and their receptors), but recently it was suggested that CXCL12 is also bound by CXCR7 receptor. The gene for CXCL12 is located on human chromosome 10. In human and mouse both CXCL12 and CXCR4 show high identity of sequence: 99% and 90%, respectively. The specific activity as determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/mL. Synonyms: SDF-1, CXCL12, Pre-B cell growth-stimulating factor, PBSF, hIRH, chemokine (C-X-C motif) ligand 12, SDF1, SDF1A, TPAR1, SCYB12, SDF-1a, TLSF-a.

rec. Human Stromal Cell-Derived Factor-1 alpha (rHuSDF-1a) 1 mg

rec. Human Stromal Cell-Derived Factor-1 alpha (rHuSDF-1a) 1 mg

Productnumber: C6059.1000

Deutsch rec. Human Stromal Cell-Derived Factor-1 alpha (rHuSDF-1a) 1 mg
Antikörper & Zytokine

Source: Escherichia Coli.

Technical Data: Purity: > 99.0% (by RP-HPLC, IEX-HPLC, SDS-PAGE). Less than 1% dimers and aggregates. Sterile Filtered White lyophilized (freeze-dried) powder. It is recommended to reconstitute the lyophilized rHuSDF-1alpha in sterile 18 Ohm/cm water not less than 100 µg/mL, which can be further diluted to other aqueous solutions.

Shipping/Storing-Information: shipped at RT, stored at -20°C

Documentation:


pdf rec. Human Stromal Cell-Derived Factor-1 alpha (rHuSDF-1a) 1 mg

Productdetails:


pdf rec. Human Stromal Cell-Derived Factor-1 alpha (rHuSDF-1a) 1 mg

Matchcode: Stromal Cell-Derived Factor-1 alpha rHuSDF-1a