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rec. Murine Insulin-Like Growth Factor I (rmlGF-I)

1 mg

Lyophilized after extensive dialysis against 0.2µm-filtered solution in PBS. Synonyms: Somatomedin C, IGF-I, IGFIA, IGF1.

1788,31 € (EUR)

plus 19% VAT and
shipping costs

Recombinant murine IGF-I produced in E.Coli is a single, non-glycosylated, polypeptide chain of 70 amino acids and a molecular mass of 7,600 Dalton. The ED50, calculated by the dose-dependant proliferation of murine BALBC 3T3 cells (measured by 3H-thymidine uptake) is 1.0ng/mL, corresponding to a specific activity of 1 x 10(6) U/mg. For most in-vitro applications, IGF-I exerts its biological activity in the concentration range of 0.2-20ng/mL. The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003).

rec. Murine Insulin-Like Growth Factor I (rmlGF-I) 1 mg - C6031.

rec. Murine Insulin-Like Growth Factor I (rmlGF-I) 1 mg - C6031.

Productnumber: C6031.1000

Deutsch rec. Murine Insulin-Like Growth Factor I (rmlGF-I) 1 mg
Antikörper & Zytokine

Source: Escherichia Coli.

Technical Data: Purity: >98.0% (by RP-HPLC, IEX-HPLC, SDS-PAGE). Less than 1% dimers and aggregates. Sterile Filtered White lyophilized (freeze-dried) powder. The lyophilized rmIGF-I is soluble in water and most aqueous buffers above the isoelectric point (pI=7.6). Endotoxin: Less than 0.1 ng/µg (IEU/µg) rmIGF-I.

Shipping/Storing-Information: shipped at RT, stored at -20°C

Productdetails:


pdf rec. Murine Insulin-Like Growth Factor I (rmlGF-I) 1 mg

Matchcode: Insulin-Like Growth Factor I rmlGF-I igf1 igf-1