rHuSTAT-1 1mg

Rec. Human signal transducer and activator of transcription 1-alpha/beta. Synonyms: Transcription factor ISGF-3 components p91/p84, STAT1, ISGF-3, STAT91, DKFZp686B04100.

Rec. human STAT1 from E.Coli is a single, non-glycosylated polypeptide of 732 amino acids (1-712 a.a.) and a molecular mass of 85.2 kDa. The STAT1 protein is fused to 20 amino acid His-Tag at the N-terminus. STAT1 is a member of the Signal Transducers and Activators of Transcriptionfamily of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I or type II interferons. In response to IFN-gamma stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element. In response to either IFN-alpha or IFN-beta stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).