rec. Aprotinin

250 mg

Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512 Daltons. Trasylor®, TKI, BPTI.

Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins.

Documentation:

  rec. Aprotinin 250 mg

Productnumber: M6383.0250

Qualitycontrol: "1 unit is defined as ""The decrease of 2 trypsin units by 50% where 1 trypsin unit will hydrolyse 1.0 umole of N(alpha)-benzoyl-DL-arginine p-nitroanilide (BAPNA) per minute at pH 7.8 at 25°C""."

Technical Data: "Assay: about 99,00%; acitivity: min. 6x10(6) IU/mg; pH (1%, H2O) = 5.0 - 7.5; water (K.F.): max. 6%; C294H432N84O79S7; MW = 6511.52 g/mol; CAS: [9087-70-1]."

Shipping/Storing-Information: shipped at RT, store at +2°C to +8°C.

Deutsche Produktseite:
rec. Aprotinin 250 mg  Chemicals

Matchcode: aprotinin TKI BPTI