FSL-2

1 mg

Lipopeptides

N-terminal part of the lipoprotein LP44 of Mycoplasma salivarium with an amino acid substitution (F - R). Pam2Cys-GDPKHPKSR. Mixture of RR and RS stereoisomers. For a complete list of all lipoproteins see attachement.

FSL-1 showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha ?and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was shown that the activity of FSL-1 is TLR2 and TLR6 dependent. A single amino acid substitution from F to R (FSL-2, Pam2Cys-GDPKHPKSR, Cat-No- P2219) and a fatty acid substitution from palmitic acid to stearic acid (FSL-3, Ste2Cys-GDPKHPKSF, Cat-No. P2220) reduced the activity significantly (Okusawa et al. 2004). FSL-1 (P2212) is more favourable than MALP-2 with respect to solubility in aqueous solutions. Genaxxon offers further MALP-2 analogues differing in the peptide moiety for improved physico-chemical features and high reproducible biological activity. Please inquire for other peptides or more information: info@genaxxon.com.

Productnumber: P2219.0001

Productdetails:

  FSL-2 1 mg

Shipping/Storing-Information: shipped at RT, store at +2°C to +8°C

Deutsche Produktseite:
FSL-2 1 mg  Services

Matchcode: lipoprotein LP44