Coprogen 1 mg

Siderophores

Coprogen and Desferri Coprogen are belonging to the hydroxamate type siderophores. Uptake by the transporter system: FhuE, FhuBCD, TonB, ExbBD.

A Siderophore (Greek for iron carrier) is an iron chelating compound secreted by microorganisms. Iron Fe3+ ions have a very low solubility at neutral pH and therefore cannot be utilized by organisms. Siderophores dissolve these ions by chelation as soluble Fe3+ complexes that can be taken up by active transport mechanisms. Many siderophores are nonribosomal peptides. Examples of siderophores produced by various bacteria and fungi are ferrichrome (Ustilago sphaerogena), enterobactin (Escherichia coli), mycobactin (Mycobacterium), enterobactin and bacillibactin (Bacillus subtilis), ferrioxamine B (Streptomyces pilosus), fusarinine C (Fusarium roseum), yersiniabactin (Yersinia pestis), vibriobactin (Vibrio cholerae), azotobactin (Azotobacter vinelandii), pseudobactin (Pseudomonas B 10), erythrobactin (Saccharopolyspora erythraea) or ornibactin (Burkholderia cepacia).