Catalogue > Biochemicals > Proteasome-Inhibitors > S5307.0200

Clasto-Lactacystin beta-lactone 200 µg - S5307.0200

540,79 EUR

excl. Shipping costs Product No.: S5307.0200


Package Size: 200 µg About 20-fold more potent than lactacystein. Lactacystin is converted to clasto-lactacystin beta-lactone in culture media and in cells where it covalently binds to catalytic subunits of the proteasome. Fenteany, G. et al., Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. (1995) 268, 726. Dick, L.R. et al. Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone., J. Biol. Chem. (1996) 271, 7273. Dick, L.R. et al. Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells., et al.; J. Biol. Chem. (1997) 272, 182.

pdf Clasto-Lactacystin beta-lactone Manual / Certificate (pdf)

Source: synthetic

Technical Data: min. 95%, white solid substance, soluble in DMSO, insoluble in water; C10H15NO4; MW = 213.2 g/mol; CAS: [155975-72-7].

Shipping / Storing Information: shipped at RT, stored at -20°C, keep tightly sealed.

Productnumber: S5307.0200

changedate: 6.3.2002


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