0,00 €*
Positionen anzeigen
 
 

Alzheimer

Characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long amyloid-β-peptides, which form insoluble fibrils via self-assembly. The amyloid-β-peptides are fragments of the broadly distributed, membrane-bound amyloid precursor protein APP, encoded on chromosome 21. They are formed from the proteolytic cleavage of APP by β- and γ-secretases.
Cleavage occurs after residue 40 or after residue 42. Even slightly increased amounts of amyloid-β-1-42 are described to be sufficient to cause Alzheimer's disease.
References:
M. Ahmed, J. Davis, D. Aucoin, T. Sato, S. Ahuja, S. Aimoto, J. I. Elliott, W. E. Van Nostrand, S. O. Smith (2010) Nat. Struct. Mol. Biol. 17, 561-567.
T. Hartmann, S. C. Bieger, B. Brühl, P. J. Tienari, N. Ida, D. Allsop, G. W. Roberts, C. L. Masters, C. G. Dotti, K. Unsicker, K. Beyreuther (1997) Nat. Med. 3, 1016-1020.

   
 
Kein Bild vorhanden Ac-KLVFF-NH2

Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were...

ab 145,23 € *

Kein Bild vorhanden Amyloid-beta (1-40) human

Amyloid-ß-peptides: Characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long...

ab 220,60 € *

Kein Bild vorhanden Amyloid-beta (1-40) human (HCl Salz)

Amyloid-ß-peptides: Characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long...

ab 364,66 € *

Kein Bild vorhanden Amyloid-beta (1-40) Ratte

Amyloid-ß-peptides: Characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long...

ab 220,60 € *

Kein Bild vorhanden Amyloid-beta (1-40) Ratte (HCl Salz)

Amyloid-ß-peptides: Characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long...

ab 364,66 € *

Kein Bild vorhanden Biotinyliertes Amyloid-beta (1-40) human

Biotinylated amyloid-ß-peptides: Biotinylated peptides are a useful tool in many important applications. Biotin has a strong affinity for avidin or streptavidin. This...

ab 431,63 € *

Kein Bild vorhanden Biotinyliertes Amyloid-beta (1-40) Ratte

Biotinylated amyloid-ß-peptides: Biotinylated peptides are a useful tool in many important applications. Biotin has a strong affinity for avidin or streptavidin. This...

ab 431,63 € *

Kein Bild vorhanden DWGKGGRWRLWPGASGKTEA

Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were...

ab 190,04 € *

Kein Bild vorhanden FYLKVPSSLHHHHGRDKLVFFHHHH

Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were...

ab 190,04 € *

Kein Bild vorhanden HNHKLVFFHHQH

Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were...

ab 145,23 € *

Kein Bild vorhanden KLVFF

Biotinylated amyloid-ß-peptides: Biotinylated peptides are a useful tool in many important applications. Biotin has a strong affinity for avidin or streptavidin. This...

ab 145,23 € *

Kein Bild vorhanden Kontrollpeptid Amyloid-beta (40-1) human

Amyloid-ß-peptides: Characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long...

ab 220,60 € *

Kein Bild vorhanden Kontrollpeptid Amyloid-beta (40-1) Ratte

Amyloid-ß-peptides: Characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long...

ab 220,60 € *

Peptid: NYSKMIFSHHHH

Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were...

ab 145,23 € *

Kein Bild vorhanden PGRSPFTGKKLFNQEFSQDQ

Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were...

ab 190,04 € *

Kein Bild vorhanden qshyrhispaqv (D-Aminosäuren)

Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were...

ab 190,04 € *

Kein Bild vorhanden RIIGL

Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were...

ab 145,23 € *

   
 

Tagwolke