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Lipopeptide

Lipoproteine sind Teil der äußeren Membran von Gram-negativen, Gram-positiven Bakterien und Mykoplasmen. Bakterielle - einschließlich mykoplasmale - Lipoproteine (bLP) sind durch den Einbau der ungewöhnlichen Aminosäure Dihydroxypropylcystein (Dhc), die durch zwei oder drei Fettsäuren acyliert ist, charakterisiert.

Synthetische Analoga (sLP) und die N-terminalen Teile des Lipoproteins von E.coli agieren in-vivo und in-vitro als potente Immunoadjuvanzien. Die Immunisierung von Meerschweinchen und Schweinen mit einem komplett synthetischen Vaccin, bestehend aus dem Lipotripeptid-Adjuvant Pam3Cys-Ser-Ser sowie aus B- und T-Zell-Epitopen des Maul-und-Klauenseuchevirus, führte zu einem lang anhaltenden Schutz gegen diesen Virus.

Die Konjugation von Class-I Peptiden mit Pam3Cys-Ser-Ser war zum ersten Mal im Jahr 1989 erfolgreich und resultierte in einer effizienten Anregung von virusspezifischer T-Zell Toxizität.

Das äußere Membran-Lipoprotein (OspA) aus Borrelia burgdorferi wurde in humanen Impfversuchen getestet und ergab sogar dann einen wirksamen Schutz, wenn es oral verabreicht wurde (Mausversuche).

   
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FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

ab 225,00 € *

FSL-1 (Pam2CysGDPKHPKSF) - R,S-stereoisomer

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

ab 225,00 € *

FSL-1 FLAG-tag TLR2/TLR6 Agonist

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

ab 225,00 € *

FSL-1 TLR2/TLR6 Agonist

FSL-1 (Pam2C-GDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2...

445,00 € *

FSL-1-Biotin TLR2/TLR6 Agonist

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

ab 225,00 € *

FSL-1-Fluorescein TLR2/TLR6 Agonist

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

ab 225,00 € *

FSL-1-Rhodamin TLR2/TLR6 Agonist

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

ab 225,00 € *

Kein Bild vorhanden Lipobiotin

Lipobiotin is a selectively biotinylated analogue of PHC-SKKKK. Biotin is attached via spacer molecules to the side chain of the C-terminal lysine. The Biotin-avidin or...

ab 225,00 € *

Lipopeptid Dhc-GDPKHPKSF

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

282,28 € *

Lipopeptid Dhc-SKKKK

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

170,95 € *

Kein Bild vorhanden Lipopeptid GDPKHPKSF

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

282,28 € *

Lipopeptid Pam-Dhc-GDPKHPKSF

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

298,80 € *

Lipopeptid Pam-Dhc-SKKKK

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

211,31 € *

Lipopeptid PamCSKKKK

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

211,31 € *

Kein Bild vorhanden Lipopeptid SKKKK

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

172,15 € *

Lipopeptide PamCGDPKHPKSF

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

414,73 € *

MALP-2-DI (Pam2CysGNNDESNISFKEKDI) -...

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

360,00 € *

MALP-2-DI (Pam2CysGNNDESNISFKEKDI) -...

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

360,00 € *

Pam2Cys-SKKKK

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

ab 145,00 € *

Pam2Cys-SKKKK-FLAG-tag

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

ab 225,00 € *

Pam2Cys-SKKKK(Biot-Aca-Aca)-NH2

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

ab 225,00 € *

Pam2Cys-SKKKK(Fluorescein-Aca-Aca)-NH2

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

ab 225,00 € *

Pam2Cys-SKKKK(Rhodamine-Aca-Aca)-NH2

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

ab 225,00 € *

Pam3Cys-SKKKK

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

ab 178,85 € *

Pam3Cys-SKKKK (Biotin-Aca-Aca)

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

ab 225,00 € *

Pam3Cys-SKKKK (Fluorescein-Aca-Aca)

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

ab 225,00 € *

Kein Bild vorhanden Pam3Cys-SKKKK (Rhodamin-Aca-Aca)

Triacyl-Lipopeptid. The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and...

ab 225,00 € *

Kein Bild vorhanden Pam3Cys-SKKKK-FLAG-tag

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

ab 225,00 € *

Pam3CysAQEKEAKSELDYDQT

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

618,76 € *

Pam3CysGSHQMKSEGHANMQL

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

618,76 € *

Pam3CysKQNVSSLDEKNSVSV

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

618,76 € *

Pam3CysNNGGPELKSDEVAKS

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

618,76 € *

Pam3CysNNSGKDGNTSANSAD

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

618,76 € *

Pam3CysSQEPAAPAAEATPAG

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

618,76 € *

Pam3CysSSGNKSAPSSSASSS

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

618,76 € *

   
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