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FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer
 
 
 

FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer

Gewicht

Reinheit

Hersteller Genaxxon bioscience



Artikel-Nr.: P2214.0001

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Produktinformationen "FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer"

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was shown that the activity of FSL-1 is TLR2 and TLR6 dependent. A single amino acid substitution from F to R (FSL-2, Pam2Cys-GDPKHPKSR, Cat-No- P2219) reduced the activity significantly (Okusawa et al. 2004). FSL-1 (P2212) is more favourable than MALP-2 with respect to solubility in aqueous solutions. FSL-1 is provided as stereochemically defined compounds and as mixture of stereoisomers. Lipopeptides with the S-dihydroxypropyl moiety are not active and therefore suitable as negative controls. Additionally, analogues with different labels or tags are available. Genaxxon offers further analogues differing in the peptide moiety for improved physico-chemical features and high reproducible biological activity. Please inquire for other peptides or more information: info@genaxxon.com.

 
 
 

Technische Daten:

The naturally occurring RR-stereoisomer of Pam2Cys, R-Pam2Cys, is described to be biologically more active than the S-stereoisomer S-[2,3-bis(palmitoyloxy)-2(S)-propyl]-(R)-cysteine. Sequence: Pam2CysGDPKHPKSF. MW = 1665 g/mol

Quelle

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90

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