A special regulatory strategy of genome translation in RNA viruses and bacterias is mediated via RNA thermometers. RNA thermometers (RNATs) are secondary structures in RNA sequences that are essential for the virulence of the organism. However the base pairing in the RNA thermometers can be altered due to various factors like the thermal denaturation.
With the virus already claiming the lives of 1,873 people and infecting 73,333 people around the globe, there is an urgent need to have a strong grip on the virus. Scientists overall are publishing new information in this regard almost every day, one of which is that 2019-nCoV uses the same ACE2 protein to enter the host cells as SARS coronavirus did.
With humankind facing a new virus outbreak every now and then, everyone is in the race to develop therapeutics. Out of all the available methods to do so involves knowing the interacting proteins of the pathogen and hosts. The method that uses this approach is known as Epitope Mapping and involves two general strategies.