rec. Human Interleukin-2 (rHuIL-2)
Artikel-Nr.: C6022.0010
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IL-2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4I and interleukin 7 (IL-7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Recombinant Human IL-2 produced in E.coli is a single, non-glycosylated polypeptide of 133 amino acids and a molecular weight of 15.4 kDa.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of murine CTLL cells is <0.1ng/mL, corresponding to a Specific Activity of 10E7 IU/mg.
Amino acid sequence
APTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLT
Technische Daten:
Specifications:
Purity: >98.0% (HPLC).
Sterile Filtered White lyophilized (freeze-dried) powder.
The lyophilized rHuIL-2 is soluble in water and most aqueous buffers below and above the isoelectric point (7.44).
Quelle
Escherichia Coli.Sicherheits Hinweise / Safety
Klassifizierungen / Classification
eclass-Nr: 32-16-04-90Dokumente - Protokolle - Downloads
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