rec. Human Interleukin-7 (rHuIL-7)

IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.

Recombinant Human Interleukin-7 from E.Coli is a single, non-glycosylated polypeptide chain of 153 amino acids and a molecular mass of 17.4 kDa.

Synonyms: Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7.

Biological activity: The ED₅₀ as determined by the dose-dependant stimulation of murine 2E8 cells is < 0.5ng/mL, corresponding to a specific activity of 2,000,000 IU/mg.

Amino acid sequence: MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH.