Cas9-NLS (CRISPR associated protein 9)

Cas9-NLS (CRISPR associated protein 9)


Artikel-Nr.: S5336.0010

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The Genaxxon Cas9-NLS represents the wild-type Cas9 nuclease from S. pyogenes , fused with a... mehr
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The Genaxxon Cas9-NLS represents the wild-type Cas9 nuclease from S. pyogenes, fused with a C-terminal NLS. Currently, the best-established Cas9 protein in the field with most publications. Cas9-NLS (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme associated with the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) adaptive immunity system in Streptococcus pyogenes, among other bacteria. S. pyogenes utilizes Cas9 to remember and later probe and cleave foreign DNA, such as invading bacteriophage DNA or plasmid DNA. In the case that the DNA substrate is complementary to the guide RNA, Cas9 cleaves the invading DNA. In addition to its original role in bacterial immunity, the Cas9 protein has been heavily employed as a genome engineering tool to induce site-directed double strand breaks in DNA. These disruptions may lead to gene inactivation or the presentation of heterologous genes via non-homologous end joining and homologous recombination respectively in many laboratory model organisms.

Recombinant Cas9-NLS comprises the entire Cas9 protein sequence and the nuclear localization sequence PKKKRKV (= NLS of Simian virus 40) at the C-terminus. The protein has an apparent molecular weight of 160kDa on SDS-PAGE.

Synonyms: CRISPR-associated endonuclease Cas9/Csn1, SpyCas9, cas9, csn1.

Cas9-NLS-Proteine von Genaxxon: Cas9-NLS (Nuklease, Wildtyp) >, Cas9-NLS-tagRFP (Nuklease mit rot fluoreszierendem Proteinmarker) >, Cas9-Dead-NLS >, Cas9-Dead-NLS-EGFP >.

Transfektionsreagenz für die Co-Transfektions RNA/Protein, speziell entwickelt für den Einsatz in CRISPR/Cas9-Systemen: CRISPRfect E >.

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Specific genome targeting Labelling of target sites.
Purity: >97% (determined by SDS-PAGE). Recombinant Cas9-NLS comprises the entire Cas9... mehr
 

Technische Daten:

Purity: >97% (determined by SDS-PAGE).

Recombinant Cas9-NLS comprises the entire Cas9 protein sequence and the nuclear localization sequence PKKKRKV (= NLS of Simian virus 40) at the C-terminus. The protein has an apparent molecular weight of 160kDa on SDS-PAGE.

Applikation:

CRISPR Cas9 Cloning

Quelle

E.coli

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

Dokumente - Protokolle - Downloads mehr

Dokumente - Protokolle - Downloads

Hier finden Sie Informationen und weiterführende Literatur zu Cas9-NLS (CRISPR associated protein 9). Für weitere Dokumente (Zertifikate mit weiteren Lotnummern, Sicherheitsdatenblätter in anderer Sprache, weitere Produktinformationen) wenden Sie sich bitte an Genaxxon biosience unter: info@genaxxon.com oder Tel.: +49 731 3608 123.

 
 
 
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