Lipopeptide

Lipoproteine sind Teile der äußeren Membran von Gram-negativen und Gram-positiven Bakterien sowie von Mykoplasmen. Bakterielle - einschließlich mykoplasmale - Lipoproteine (bLP) sind durch den Einbau der ungewöhnlichen Aminosäure Dihydroxypropylcystein (Dhc), die durch zwei oder drei Fettsäuren acyliert ist, charakterisiert.

Synthetische Analoga (sLP) und die N-terminalen Teile des Lipoproteins von E.coli agieren in-vivo und in-vitro als potente Immunoadjuvantien. Die Immunisierung von Meerschweinchen und Schweinen mit einem komplett synthetischen Vaccin, bestehend aus dem Lipotripeptid-Adjuvant Pam3Cys-Ser-Ser sowie aus B- und T-Zell-Epitopen des Maul-und-Klauenseuchevirus, führte zu einem lang anhaltenden Schutz gegen dieses Virus.

Die Konjugation von Class-I Peptiden mit Pam3Cys-Ser-Ser war zum ersten Mal im Jahr 1989 erfolgreich und resultierte in einer effizienten Anregung von virusspezifischer T-Zell-Toxizität.

Das äußere Membran-Lipoprotein (OspA) aus Borrelia burgdorferi wurde in humanen Impfversuchen getestet und ergab sogar dann einen wirksamen Schutz, wenn es oral verabreicht wurde (Mausversuche).

Lipoproteine sind Teile der äußeren Membran von Gram-negativen und Gram-positiven Bakterien sowie von Mykoplasmen. Bakterielle - einschließlich mykoplasmale - Lipoproteine (bLP) sind durch den... mehr erfahren »
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Lipopeptide

Lipoproteine sind Teile der äußeren Membran von Gram-negativen und Gram-positiven Bakterien sowie von Mykoplasmen. Bakterielle - einschließlich mykoplasmale - Lipoproteine (bLP) sind durch den Einbau der ungewöhnlichen Aminosäure Dihydroxypropylcystein (Dhc), die durch zwei oder drei Fettsäuren acyliert ist, charakterisiert.

Synthetische Analoga (sLP) und die N-terminalen Teile des Lipoproteins von E.coli agieren in-vivo und in-vitro als potente Immunoadjuvantien. Die Immunisierung von Meerschweinchen und Schweinen mit einem komplett synthetischen Vaccin, bestehend aus dem Lipotripeptid-Adjuvant Pam3Cys-Ser-Ser sowie aus B- und T-Zell-Epitopen des Maul-und-Klauenseuchevirus, führte zu einem lang anhaltenden Schutz gegen dieses Virus.

Die Konjugation von Class-I Peptiden mit Pam3Cys-Ser-Ser war zum ersten Mal im Jahr 1989 erfolgreich und resultierte in einer effizienten Anregung von virusspezifischer T-Zell-Toxizität.

Das äußere Membran-Lipoprotein (OspA) aus Borrelia burgdorferi wurde in humanen Impfversuchen getestet und ergab sogar dann einen wirksamen Schutz, wenn es oral verabreicht wurde (Mausversuche).

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PHC-SKKKK PHC-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
217,48 € *
Lipopeptide Pam3CysSSNAKIDQLSSDVQT Pam3CysSSNAKIDQLSSDVQT
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Lipopeptide Pam3CysSSNKSTTGSGETTTA Pam3CysSSNKSTTGSGETTTA
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Lipopeptide Pam3CysSSTKPVSQDTSPKPA Pam3CysSSTKPVSQDTSPKPA
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Lipopeptide Pam3CysSSGSKPSGGPLPDAK Pam3CysSSGSKPSGGPLPDAK
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Lipopeptide Pam3CysSSGNKSAPSSSASSS Pam3CysSSGNKSAPSSSASSS
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Pam3CysGSHQMKSEGHANMQL Pam3CysGSHQMKSEGHANMQL
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Pam3CysSSSNNDAAGNGAAQT Pam3CysSSSNNDAAGNGAAQT
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Pam3CysKQNVSSLDEKNSVSV Pam3CysKQNVSSLDEKNSVSV
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Pam3CysNNSGKDGNTSANSAD Pam3CysNNSGKDGNTSANSAD
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Pam3CysNNGGPELKSDEVAKS Pam3CysNNGGPELKSDEVAKS
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Pam3CysSQEPAAPAAEATPAG Pam3CysSQEPAAPAAEATPAG
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
482,71 € *
Pam3CysSSSKSSDSSAPKAYG Pam3CysSSSKSSDSSAPKAYG
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
477,41 € *
Pam3CysAQEKEAKSELDYDQT Pam3CysAQEKEAKSELDYDQT
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
493,32 € *
Lipopeptide Pam2Cys-SKKKK Pam2Cys-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
ab 153,83 € *
FSL-1 TLR2/TLR6 Agonist FSL-1 TLR2/TLR6 Agonist
FSL-1 (Pam2C-GDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
472,10 € *
FSL-1 FLAG-tag TLR2/TLR6 Agonist FSL-1 FLAG-tag TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
ab 238,70 € *
Lipopeptid Pam-Dhc-SKKKK Lipopeptid Pam-Dhc-SKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
217,48 € *
Lipopeptid Pam-Dhc-GDPKHPKSF Lipopeptid Pam-Dhc-GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
328,88 € *
Lipopeptid PamCSKKKK Lipopeptid PamCSKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
217,48 € *
Lipopeptide PamCGDPKHPKSF Lipopeptide PamCGDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
355,40 € *
Lipopeptid Dhc-SKKKK Lipopeptid Dhc-SKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
196,27 € *
Lipopeptid Dhc-GDPKHPKSF Lipopeptid Dhc-GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
299,47 € *
Lipopeptid SKKKK Lipopeptid SKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
206,88 € *
Lipopeptid GDPKHPKSF Lipopeptid GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK > , Pam2Cys-SKKKK > or FSL-1 > are analogues or substructures of TLR2 ligands...
299,47 € *
Pam3Cys-SKKKK (Biotin-Aca-Aca) Pam3Cys-SKKKK (Biotin-Aca-Aca)
Das synthetische, triacyliertes Pam3Cys-SKKKK > repräsentiert das N-terminale Ende vom bakteriellen Lipoprotein Pam3Cys-AA15. Pam3Cys-SKKKK ist das meist eingesetzte, synthetische Analog zu natürlich vorkommenden Lipoproteinen und oft in...
ab 238,70 € *
R-Pam3Cys-SKKKK R-Pam3Cys-SKKKK
Pam3Cys-SKKKK is the mostly used synthetic analogue of naturally occurring lipoproteins and often described in literature as reference compound for TLR2/1 activation. Pam3Cys-SKKKK is provided as stereochemically defined compound and as...
ab 238,70 € *
Pam3Cys-SKKKK (Fluorescein-Aca-Aca) Pam3Cys-SKKKK (Fluorescein-Aca-Aca)
Pam3Cys-SKKKK is the mostly used synthetic analogue of naturally occurring lipoproteins and often described in literature as reference compound for TLR2/1 activation. Pam3Cys-SKKKK is provided as stereochemically defined compound and as...
ab 238,70 € *
S-Pam3Cys-SKKKK S-Pam3Cys-SKKKK
Pam3Cys-SKKKK is the mostly used synthetic analogue of naturally occurring lipoproteins and often described in literature as reference compound for TLR2/1 activation. Pam3Cys-SKKKK is provided as stereochemically defined compound and as...
ab 238,70 € *
Pam3Cys-SKKKK (Rhodamin-Aca-Aca) Pam3Cys-SKKKK (Rhodamin-Aca-Aca)
Triacyl-Lipopeptid. The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins...
ab 238,70 € *
Pam3Cys-SKKKK-FLAG-tag Pam3Cys-SKKKK-FLAG-tag
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
ab 238,70 € *
Lipobiotin - PHC-KKKKK(Biotin-Aca-Aca) Lipobiotin - PHC-KKKKK(Biotin-Aca-Aca)
Lipobiotin - PHC-KKKKK(Biotin-Aca-Aca) is a selectively biotinylated analogue of PHC-SKKKK ( P2232 > ). Biotin is attached via spacer molecules to the side chain of the C-terminal lysine. The Biotin-avidin or -streptavidin interaction...
ab 259,92 € *
R-Pam2Cys-SKKKK R-Pam2Cys-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
ab 238,70 € *
S-Pam2Cys-SKKKK S-Pam2Cys-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
ab 238,70 € *
Pam2Cys-SKKKK(Biotin-Aca-Aca)-NH2 Pam2Cys-SKKKK(Biotin-Aca-Aca)-NH2
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
ab 238,70 € *
Pam2Cys-SKKKK(Rhodamine-Aca-Aca)-NH2 Pam2Cys-SKKKK(Rhodamine-Aca-Aca)-NH2
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
ab 238,70 € *
Pam2Cys-SKKKK-Flag peptide Pam2Cys-SKKKK-FLAG-tag
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
ab 238,70 € *
FSL-1 (Pam2CysGDPKHPKSF) - R.S-stereoisomer FSL-1 (Pam2CysGDPKHPKSF) - R.S-stereoisomer
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
ab 238,70 € *
FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
ab 238,70 € *
FSL-1-Biotin TLR2/TLR6 Peptid FSL-1-Biotin TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
ab 238,70 € *
FSL-1-Fluorescein TLR2/TLR6 Peptid FSL-1-Fluorescein TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
ab 238,70 € *
FSL-1-Rhodamin TLR2/TLR6 Peptid FSL-1-Rhodamin TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
ab 238,70 € *
MALP-2-DI (Pam2Cys-GNNDESNISFKEKDI) Peptide MALP-2-DI (Pam2CysGNNDESNISFKEKDI) -...
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
381,92 € *
MALP-2-DI (Pam2Cys-GNNDESNISFKEKDI) Peptide MALP-2-DI (Pam2CysGNNDESNISFKEKDI) -...
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
477,41 € *
PamCys(Pam)-SKKKK PamCys(Pam)-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
ab 238,70 € *
Pam2Cys-SKKKK(Fluorescein-Aca-Aca)-NH2 Pam2Cys-SKKKK(Fluorescein-Aca-Aca)-NH2
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
ab 238,70 € *
Pam3Cys-SKKKK Pam3Cys-SKKKK
Pam3Cys-SKKKK is the mostly used synthetic analogue of naturally occurring lipoproteins and often described in literature as reference compound for TLR2/1 activation. Pam3Cys-SKKKK is provided as stereochemically defined compound and as...
ab 188,84 € *