Pam3Cys-SKKKK

Pam3Cys-SKKKK is the mostly used synthetic analogue of naturally occurring lipoproteins and often described in literature as reference compound for TLR2/1 activation. Pam3Cys-SKKKK is provided as stereochemically defined compound and as a mixture of stereoisomers. Additionally, labelled analogues are available. PHC-SKKKK > is recommended as an appropriate negative control. This triacylated lipopeptide does not contain the dihydroxypropyl cysteine residue, which seems to be essential for the interaction with TLR1/2.

Pam3Cys-SKKKK is a synthetic, triacylated lipopeptide that represents the N-terminal lipohexadecapeptide sequence, Pam3Cys-AA15, of bacterial lipoproteins. The peptide is delivered as hydrochloric acid salt!

The C-terminal COOH and the NH2 groups in the side chains of the four lysines are available for modification but can not be addressed specifically. Conjugation will lead to a mixture of products. If a specific conjugation to e.g. the side chain of the C-terminal lysine is required, please inquire for custom specific lipopeptide synthesis. Dependent on the compound which should be conjugated we might be able to offer it also from stock (e.g. biotinylation or dye labelled lipopeptides (P2207 >, P2209 >, P2211 >).