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Thrombospondin is a large, trimeric, modular glycoprotein composed of three identical subunits... mehr
Produktinformationen "rHu Thrombospondin - 1 mg"
Thrombospondin is a large, trimeric, modular glycoprotein composed of three identical subunits with 1170 amino acids. It is a major constituent of platelets released from its alpha-granules in response to thrombin stimulation. TSP is also a transient component of extracellular matrix in developing and repairing tissues. TSP is a multifunctional protein consisting of distinct structural domains. It contains an aminoterminal domain with a heparin-binding site, a segment that is homologous to the alpha1 chain of type 1 procollagen (PC), three type 1 (properdin) repeats, three type 2 (EGF-like) repeats, seven type 3 (Ca-binding) repeats and a carboxy-terminal cell-binding domain. The different segments are assigned to cell attachment, cell movement, modulation of proliferation, platelet aggregation, modulation of angiogenesis, neurite outgrowth and platelet aggregation.TSP is synthesized and secreted by platelets, fibroblasts, endothelial cells, smooth muscle cells and tumour cells. It functions in proliferation of cells, wound healing, angiogenesis and tumorigenesis.
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Purity: >95% (SDS-PAGE); Identity: tested with polyclonal antibodies; Activity: tested in... mehr
Technische Daten:Purity: >95% (SDS-PAGE); Identity: tested with polyclonal antibodies; Activity: tested in functional and cell adhesion assays; MW=non-reduced band at 450 kDa.
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 32-16-04-05
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