Amyloid-beta (16-20) KLVFF Inhibitorpeptid von Amyloid-beta

Amyloid-beta (16-20) KLVFF Inhibitorpeptid von Amyloid-beta


Artikel-Nr.: P2255.9505

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The KLVFF peptide is one of several inhibitors of amyloid-beta aggregation that have been... mehr
Produktinformationen "Amyloid-beta (16-20) KLVFF Inhibitorpeptid von Amyloid-beta"

The KLVFF peptide is one of several inhibitors of amyloid-beta aggregation that have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were identified by phage display approaches. An overview about peptides that target amyloid-beta is described by Stains et al. (2007) ChemMedChem 2, 1674-1692.

The characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long amyloid-ß-peptides, which form insoluble fibrils via self-assembly. The amyloid-ß-peptides are fragments of the broadly distributed, membrane-bound amyloid precursor protein APP, encoded on chromosome 21. They are formed from the proteolytic cleavage of APP by ß- and g-secretases. Cleavage occurs after residue 40 or after residue 42. Even slightly increased amounts of amyloid-ß1-42 are described to be sufficient to cause Alzheimer's disease.

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Weitere Artikel passend zu "Amyloid-beta (16-20) KLVFF Inhibitorpeptid von Amyloid-beta"
Specifications: Purity: >95% (HPLC) Sequence: KLVFF Appearance: lyophilized, white... mehr
 

Technische Daten:

Specifications:
Purity: >95% (HPLC)
Sequence: KLVFF
Appearance: lyophilized, white powder

Applikation:

study of Alzheimer desease Fibrilization, fibrillogenesis studies

Quelle

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90
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Dokumente - Protokolle - Downloads

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