Rho1D4 / Anti-Rhodopsin Antibody

Rho1D4 antibody (antibody to Rhodopsin) is available as a purified mouse monoclonal antibody.

The Rho1D4 specifically binds to the C- terminal epitope -T-E-T-S-Q-V-A-P-A- (COOH) of rhodopsin.

This epitope can be engineered onto the C-terminus of proteins by recombinant techniques for use in
- immunocytochemical analysis of proteins
- co-immunoprecipitation
- purification of epitope-tagged proteins for structure-function studies
- related affinity-based techniques

Human rhodopsin is a G-protein coupled receptor and an integral membrane protein of the light-absorbing molecules that mediate vision. It consists of a protein, opsin, which is covalently bound to 11-cis-retinal. Rhodopsin expression has been reported in rod-shaped photoreceptor cells of the retina. Retinitis pigmentosa is a hereditary disease of photoreceptor degeneration. Phosphorylation of rhodopsin at multiple phosphorylation sites is required for its rapid and reproducible deactivation.