Lactulose crystal. (min. 98.0% HPLC)
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S5066.0025
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Product information "Lactulose crystal. (min. 98.0% HPLC)"
ß-D-Galp(1->4)-D-fruc, 4-O-β-D-Galactopyranosyl-D-fructose
Lactulose is a synthetic disaccharide composed of galactose and fructose, linked by a β-1,4-glycosidic bond. It is not hydrolyzed or absorbed in the small intestine due to the lack of human enzymes that can break this specific bond. Instead, it reaches the colon intact, where it is fermented by colonic bacteria (mainly Lactobacillus and Bifidobacterium).
Key Biochemical Aspects:
1. Fermentation & Acid Production:
- In the colon, lactulose is broken down into short-chain fatty acids (SCFAs), lactic acid, and acetic acid, lowering the colonic pH.
- This acidic environment promotes the conversion of toxic ammonia (NH₃) into its ionized form ammonium (NH₄⁺), which is less absorbable and excreted in the stool.
2. Osmotic Effect:
- The fermentation process leads to an increase in osmotic pressure, drawing water into the intestine.
- This stimulates peristalsis and helps relieve constipation.
- Lactulose promotes the growth of beneficial gut bacteria like Bifidobacteria, while suppressing harmful ammonia-producing bacteria like Clostridia.
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