Dihydrorhodamine 123 - DHR

Dihydrorhodamine 123 - DHR


Order number: S5427.0010

Shipping: Shipment: not cooled. Store at -20°C. For laboratory usage only!
CAS-Nr: 109244-58-8

Delivery time: 3- 8 working days
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€189.37 *

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Dihydrorhodamine 123 is a cell-permeable non-fluorescent substance used as an indicator for... more
Product information "Dihydrorhodamine 123 - DHR"

Dihydrorhodamine 123 is a cell-permeable non-fluorescent substance used as an indicator for reactive oxygen species (ROS) substances. Dihydrorhodamine 123 will diffuse across membranes where it is oxidized by peroxynitrite to rhodamine 123 which localizes in the mitochondria and exhibits green fluorescence (Ex/Em wavelengths of 500 and 536 nm).

Dihydrorhodamine 123 is used for investigation on reactive oxygen intermediates produced by human and murine phagocytes, activated rat mast cells and cultured endothelial cells. In addition, it has been used together with Fura Red calcium indicator to simultaneously measure oxidative bursts and Ca2+ fluxes in monocytes and granulocytes. Dihydrorhodamine 123 has been shown to be a more sensitive probe than H2DCFDA for detecting granulocyte respiratory bursts.

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Our comment on "Dihydrorhodamine 123 - DHR"
non-fluorescent turning into green fluorescence after oxidation (Ex/Em wavelengths of 500 and 536 nm).
Specifications: Purity: >95% (NMR) Identity: 1H-NMR Appearance: pink powder/solid... more
 

Technical Data:

Specifications:
Purity: >95% (NMR)
Identity: 1H-NMR
Appearance: pink powder/solid
Fluorescence: λex 500 nm, λem 525 nm in 0.1 M Tris pH 8.0 (after oxidizing with H2O2, peroxidase)
Soluble in: DMSO (5 mg/ml), DMF, chloroform, ethanol
C21H18N2O3
346.38 g/mol

application:

Cell-permeable non-fluorescent reactive oxygen species (ROS) indicator

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

CAS-Nr: 109244-58-8
eclass-Nr: 30-19-60-90
Dokumente - Protokolle - Downloads more


Dokumente - Protokolle - Downloads

Here you will find information and further literature on Dihydrorhodamine 123 - DHR. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.