rec. Human Interleukin-4 (rHuIL-4)
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Recombinant human IL-4 from E.Coli is a single, non-glycosylated polypeptide of 130 amino acids and a molecular mass of 15 kDa.
IL-4 is a pleiotropic cytokine produced by activated T cells. IL-4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL-13, which may contribute to many overlapping functions of IL-4 and IL-13.
STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. IL-4, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-4 gene particularly close to IL-13. IL-4, IL1-3 and IL-5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms: BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra.
Sequence: MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS.
Purity: min. 97% (HPLC).
IL-4 was lyophilized from a 0.2µm filtered concentrated (1mg/mL) solution in PBS, pH 7.4.
The ED50 as determined by the dose-dependent stimulation of TF-1 cells is <0.2ng/mL, corresponding to a Specific Activity of 5,000,000 IU/mg.
application:For in vitro applications. A dose-response assay should be performed to determine the optimal concentration for specific experiments.
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 34-16-04-90
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