rec. Human Interleukin-4 (rHuIL-4)
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Recombinant human IL-4 Human produced in HEK 293 cells is a glycosylated monomer, with a molecular weight range of 14-19kDa due to glycosylation.
IL-4 is a pleiotropic cytokine produced by activated T cells. IL-4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL-13, which may contribute to many overlapping functions of IL-4 and IL13.
STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. IL-4, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-4 gene particularly close to IL-13. IL-4, IL1-3 and IL-5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms: BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra.
Sequence (AA 25-153): MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS.
Purity: min. 95% (HPLC).
Sterile filtered (0.2µm filter) white lyophilized (freeze-dried) powder.
The activity was determined by the dose dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line) and was found to be 0.17ng/mL.
application:For in vitro applications. A dose-response assay should be performed to determine the optimal concentration for specific experiments. ELISA, Functional Studies, SDS-PAGE
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads
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