Melan-A / MART-1 (26-35) EAAGIGILTV - A*02:01
Advantages at a glance
- Purity: >95% (HPLC)
- Sequence: EAAGIGILTV
- HLA-type: HLA-A*02:01
- Appearance: Lyophilized white powder
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€305.50
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| From 3 |
€229.13
€305.50
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Product information "Melan-A / MART-1 (26-35) EAAGIGILTV - A*02:01"
The Melan-A (26-35) decapeptide represents the “native” form of the immunodominant antigen of the melanocyte/melanoma (Melan-A/MART) protein. It is recognized better by tumor-infiltrating lymphocytes (TILs) than Melan-A (27-35), but has a lower binding affinity and stability compared to the mutant [Leu27]-peptide with the peptide sequence: ELAGIGILTV (P2508 >).
Melan-A / MART-1 (26-35) EAAGIGILTV - A*02:01 belongs to a group of T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific sequence motifs. These antigenic peptides are derived from non-structural and structural proteins through proteolysis in the cytosolic compartment. Peptide-MHC-I complexes are then transported to the cell surface of antigen presenting cells and are recognised by CD8+ cytotoxic T lymphocytes (CTL). This interaction induces the differentiation of CTLs. Activated CTL lyse the infected cell, secrete cytokines, and proliferate. This mechanism ensures that cells infected by viruses or intracellular bacteria or cancer cells can be detected, since pathogen or cancer-specific MHC peptide complexes are displayed on the cell surface. CTL can recognise such abnormal cells and eliminate them. The genes of MHC I and II molecules are polymorphic. Each MHC allele has a distinct peptide binding motif which favours certain amino acid anchor residues at defined sequence positions.
Specifications:
Purity: >95% (HPLC)
Sequence: EAAGIGILTV
HLA-type: HLA-A*02:01
lyophilized white powder
Quelle / Source:
syntheticKlassifizierungen / Classification
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