Human ACE2 recombinant protein.(ECD, processed), Tag-free
Advantages at a glance
- High-quality products
- Customized solutions
- Personal contact
- Fast service
- Competent technical support +49(0)731-3608-123
Delivery time: 3- 8 working days
For detailed information on the delivery date, please contact Genaxxon.
Shipment: on wet ice. Store at -20°C. For laboratory usage only!
<p>Recombinant human ACE2 Protein (ECD processed). We offer high purity. and quality in HEK293 expressed recombinant protein for R&D made in Germany. As SARS-CoV.2 uses ACE2 as the entry point into cells it is one of the most important components to develop effective COVID-19 therapeutics.</p>
<p>The human Angiotensin-Converting Enzyme 2 (hACE2) is a type I transmembrane metallocarboxy-peptidase with homology to ACE, a regulator in the Renin-Angiontensin system (RAS). hACE2 is expressed at the surface of cells of all tissues shown to harbour SARS-CoV, as human lungs, arteries, kidneys, heart, and intestine.</p>
<p>ACE-2 is known to control blood pressure by the hydrolysis of a small peptide hormone called Angiotensin II into Angiotensin 1-7 by ACE and other endopeptidases, Angiontensin 1-7 acts in a vasoconstricting manner and is therefore involved in diabetes, hypertension, and cardiac function in general. SARS-CoV.2 uses ACE2 as the entry point into alveolar cells of the lungs, where it replicates and causes the Coronavirus disease (COVID-19).</p>
<p><strong>Sequence (AA 20-707, about 80 kDa):</strong></p>
<p style="word-wrap: anywhere;">MTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSSGGLNDIFEAQKIEWHEGSGHHHHHHHHG</p>
<p>Methionin at position 1 present due to cloning constraints. This Methionin does not belong to the ACE 2 protein sequence.</p>
<p><strong>RefSeq Links:</strong> UniProt: Q9BYF1</p>
Specifications:
Purification method: purified by IEC
Formulation: 50mM Tris, 250mM NaCl, pH8.0
Format: Liquid
Purity: >80% as determined by SDS-PAGE
Expression host: human, HEK293
Sicherheits Hinweise / Safety
Klassifizierungen / Classification
eclass-Nr: 32-16-04-09
Documents:
Category ListSource: NCBI PubMed
