rHu EpCAM - 100 µg

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Product number: S5558.0100

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Product information "rHu EpCAM - 100 µg"

Epithelial Cell Adhesion Molecule (EpCAM) also known as antigen GA733-2 is a 40 kDa transmembrane glycoprotein . It´s composed of a 242 aa extracellular domain (ED), a 23 aa transmembrane region and a 26 aa cytoplasmatic region. EpCAM is expressed is expressed in embryonic tissues and during pancreas and liver development. It functions as homotypic cell-cell adhesion molecule. In adenocarcinomas it is significantly overexpressed. EpCAM is involved in cell signaling, migration, proliferation and differentiation. The soluble, extracellular domain exists in two glycosylated forms of 32 kDa and 39kDa.

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