recombinant human ACE2 Protein (ECD), Avi/His-Tag, non-biotinylated
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Shipment: on wet ice. Store at -20°C. For laboratory usage only!
Recombinant human ACE2 Protein (ECD processed) contains an Avi/His-Tag, and is ready for invitro biotinylation. We offer high purity. and quality in HEK293 expressed recombinant protein for R&D made in Germany. As SARS-CoV.2 uses ACE2 as the entry point into cells it is one of the most important components to develop effective COVID-19 therapeutics.
The human Angiotensin-Converting Enzyme 2 (hACE2) is a type I transmembrane metallocarboxy-peptidase with homology to ACE, a regulator in the Renin-Angiontensin system (RAS). hACE2 is expressed at the surface of cells of all tissues shown to harbour SARS-CoV, as human lungs, arteries, kidneys, heart, and intestine.
ACE-2 is known to control blood pressure by the hydrolysis of a small peptide hormone called Angiotensin II into Angiotensin 1-7 by ACE and other endopeptidases, Angiontensin 1-7 acts in a vasoconstricting manner and is therefore involved in diabetes, hypertension, and cardiac function in general. SARS-CoV.2 uses ACE2 as the entry point into alveolar cells of the lungs, where it replicates and causes the Coronavirus disease (COVID-19).
Sequence without tags (AA 20-707, about 80 kDa):
MTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSSGGLNDIFEAQKIEWHEGSGHHHHHHHHG
Methionin at position 1 present due to cloning constraints. This Methionin does not belong to the ACE 2 protein sequence.
RefSeq Links: UniProt: Q9BYF1
Specifications:
Purification method: purified by IEC
Purity: >90% as determined by SDS-PAGE
Tag(s): Tag: Avi/His-Tag, C-terminal. Avi-Tag not biotinylated
Formulation: dissolved in PBS, pH7.4
Expression host: human, HEK293
Sicherheits Hinweise / Safety
Klassifizierungen / Classification
eclass-Nr: 32-16-04-09
Documents:
Product descriptionCategory List
Source: NCBI PubMed
