Chemokines

Chemokines are a subset of cytokines. They are signaling proteins (composed of 75-125 amino acids), which are responsible for chemotaxis, that is, the movement in cells and tissues, but also in the blood. They are produced and secreted by the cells themselves. The receptive for the respective chemokine cells migrate to where the highest chemokine concentration prevails. This Chemokines play an important role in the immune response, but also in organ development.

According to their chromosomal location there are two subfamilies of Chemokines:
- CXC-Chemokines (also: Alpha-Chemokines, mainly mapped on human chromosome 4; e.g. CXCL8 or rHuIL-8 for chemotaxis of neutrophile cells), with two Cysteine residues at the N-terminal end, separated by one amino acid
- CC-Chemokines (also: Beta-Chemokines, mainly mapped on human chromosome 17; e.g.human HCC-1 or rHuHCC), with two adjacent Cysteine residues at the Amino-terminal end

Chemokines are a subset of cytokines. They are signaling proteins (composed of 75-125 amino acids) , which are responsible for chemotaxis , that is, the movement in... read more »
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Chemokines

Chemokines are a subset of cytokines. They are signaling proteins (composed of 75-125 amino acids), which are responsible for chemotaxis, that is, the movement in cells and tissues, but also in the blood. They are produced and secreted by the cells themselves. The receptive for the respective chemokine cells migrate to where the highest chemokine concentration prevails. This Chemokines play an important role in the immune response, but also in organ development.

According to their chromosomal location there are two subfamilies of Chemokines:
- CXC-Chemokines (also: Alpha-Chemokines, mainly mapped on human chromosome 4; e.g. CXCL8 or rHuIL-8 for chemotaxis of neutrophile cells), with two Cysteine residues at the N-terminal end, separated by one amino acid
- CC-Chemokines (also: Beta-Chemokines, mainly mapped on human chromosome 17; e.g.human HCC-1 or rHuHCC), with two adjacent Cysteine residues at the Amino-terminal end

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Human HCC-1 (rHuHCC)
Human HCC-1 (rHuHCC)
HCC-1 is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract Human monocytes at 5.0-20.0 ng/mL.
From €178.83 *
Human MCP-2 (rHuMCP-2)
Human MCP-2 (rHuMCP-2)
MCP-2 is fully biologically active when compared to standard. The specific activity as determined by the ability of MCP-2 to chemoattract human peripheral blood at 10-100ng/mL.
From €178.83 *
humanes MCP-3 (rHuMCP-3)
humanes MCP-3 (rHuMCP-3)
From €178.83 *
HuPF-4
HuPF-4
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on...
From €170.89 *
Murine MCP-3 (rMMCP-3)
Murine MCP-3 (rMMCP-3)
Murine MCP-3 is fully biologically active when compared to standard. The specific activity as determined by the ability of Murine MCP-3 to chemoattract Balb/C mouse spleen MNCs at 10-100ng/mL.
From €178.83 *
Rat MCP-1 (MCAF), rec.
Rat MCP-1 (MCAF), rec.
rR-MCP-1 is fully biologically active when compared to standard. The specific activity as determined by the ability of Rat MCP-1 to chemoattract human peripheral blood at 10-100ng/mL.
From €178.83 *
rec. Human Interleukin-8 (aa 1-72) (rHuIL-8)
rec. Human Interleukin-8 (aa 1-72) (rHuIL-8)
Synonyms: IL-8, CXCL8, Monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived...
From €164.52 *
rec. Human Stromal Cell-Derived Factor-1 beta (rHuSDF-1b)
rec. Human Stromal Cell-Derived Factor-1 beta...
SDF-1 (stromal cell-derived factor-1) is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12). It is produced in two forms, SDF-1a/CXCL12a and SDF-1b/CXCL12b, by...
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Human MCP-4, rec.
Human MCP-4, rec.
MCP-4 is fully biologically active when compared to standard. The specific activity as determined by the ability of MCP-4 to chemoattaract human monocytes at 10-100ng/mL.
From €178.83 *
Human MIP-1alpha, rec.
Human MIP-1alpha, rec.
UV spectroscopy at 280 nm using the absorbency value of 0.9 as the extinction coefficient for a 0.1% (1mg/mL) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
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Human MIP-1beta, rec.
Human MIP-1beta, rec.
rHuMIP-1 is fully biologically active when compared to standard. The Activity is calculated by the ability to chemoattract Human blood monocytes using a concentration of 5-20 ng/mL.
From €178.83 *
Human MIP-4, rec.
Human MIP-4, rec.
Murine Macrophage Inflammatory Protein-4 is fully biologically active when compared to standard. The Activity is calculated by the ability to chemoattract Human T lymphocytes at 1.0-10.0 ng/mL.
From €178.83 *
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