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Recombinant Human IFN-g produced in E.Coli is a single, non-glycosylated, polypeptide chain of 144 amino acids and amolecular mass of 16,879 Dalton.
IFN-gamma is produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. IFN-gamma is used in the research for possible therapeutic agents against COVID-19 (Nezhad et al.: Therapeutic Approaches for COVID-19 Based on the Dynamics of Interferon-mediated Immune Responses >).
Amino Acid Sequence:
MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ.
The specific activity as determined in a viral resistance assay is < 0.05 ng/ml, corresponding to a specific activity of 2.0 x 10,000,000 IU/mg.
Synonym: Immune Interferon, type II interferon, T cell interferon, MAF, IFNG, IFG, IFI, IFN-gamma.
antiviral activity has important immunoregulatory functions is a potent activator of macrophages has antiproliferative effects on transformed cells it can potentiate the antiviral and antitumor effects of the type I interferons.
Purity: >98% (by RP-HPLC, SDS-PAGE).
Sterile filtered white lyophilized (freeze-dried) powder. The specific activity as determined in a viral resistance assay is <0.05ng/mL, corresponding to a specific activity of 2.0 x 10E7 IU/mg.
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads
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