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Rec. human Interleukin-5 produced in E.Coli is a dimeric, non-glycosylated polypeptide chain of two 113 amino acids chains, with a molecular mass of 26522.84 Dalton.
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Synonyms: EDF, BCDFII, TRF, T-cell replacing factor, Eosinophil differentiation factor, B cell differentiation factor I, IL-5.
Purity: min. 99% (HPLC).
Lyophilized from a concentrated (1mg/mL) solution in water containing no additives.
First five amino acids: Met-Ile-Pro-Thr-Glu.
The ED50 as determined by the dose-dependant stimulation of the proliferation of TF-1 cells was found to be <0.15ng/mL, corresponding to a Specific Activity of 6 x 106 IU/mg.
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads
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