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Recombinant Human IL-7 produced in E.Coli is a single, non-glycosylated polypeptide of 172 amino acids and a molecular mass of 17,412 Dalton. The ED50 as determined by the dose-dependant stimulation of murine IXN/2B cells is <0.3 ng/mL, corresponding to a Specific Activity of 1 x 10(6) IU/mg. IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.
Purity: >97% (by HPLC and SDS-PAGE)
Sterile filtered white powder lyophilized (freez-dried) from a 0.2µm filtered concentrated solution (1mg/mL) in 1X PBS, pH 7.4.
First five amino acids: DCDIE
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads
Here you will find information and further literature on rec. Human Interleukin-7 (rHuIL-7). For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: firstname.lastname@example.org or phone: +49 731 3608 123.