rec. Human Fibroblast Growth Factor-basic - (rHuFGF-b)

FGF-beta - Fibroblast Growth Factor 2


Order number: C6034.0010

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Basic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF... more
Product information "rec. Human Fibroblast Growth Factor-basic - (rHuFGF-b)"

Basic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.

Rec. human Fibroblast Growth Factor-2 (FGF-2 / FGF-basic) produced in E.Coli is a single, non-glycosylated, polypeptide chain of 154 amino acids and a molecular mass of 17.2kDa.

Biological activity: The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is <0.5ng/mL, corresponding to a specific activity of 2,000,000 Units/mg.

Amino acid sequence: AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS.

More products around "rec. Human Fibroblast Growth Factor-basic - (rHuFGF-b)"
Specifications: Purity: >98% (by HPLC) Lyophilized from a concentrated (1mg/mL) solution in... more
 

Technical Data:

Specifications:
Purity: >98% (by HPLC)
Lyophilized from a concentrated (1mg/mL) solution in PBS, pH7.4

Biological activity:
The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is <0.5 ng/mL, corresponding to a specific activity of 2,000,000 Units/mg.

Source

Escherichia Coli.

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90
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Dokumente - Protokolle - Downloads

Here you will find information and further literature on rec. Human Fibroblast Growth Factor-basic - (rHuFGF-b). For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.