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IL-2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin-4 (IL-4) and interleukin-7 (IL-7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Rec. mouse Interleukin-2 produced in E.Coli is a single, non-glycosylated polypeptide chain of 148 amino acids and a molecular mass of 17.2 kDa.
Biological Activity: The ED50 as determined by the dose-dependant stimulation of murine CTLL-2 cells is less than 0.2ng/mL corresponding to a Specific Activity of 5x106IU/mg.
Amino acid sequence: PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ.
Purity: >97% (by HPLC and SDS-PAGE)
Sterile Filtered White lyophilized (freeze-dried) powder lyophilized from a 0.2µm filtered concentrated solution (1mg/mL) in 20mM PBS, pH 7.4
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads
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