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rec. Human Interleukin-15 (rHuIL-15)

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€145.00*

Weight
Product number: C6030.0002
Delivery time: 3- 8 working days
For detailed information on the delivery date, please contact Genaxxon.

Shipment: not cooled. Stored at -20°C. For laboratory usage only!
Product information "rec. Human Interleukin-15 (rHuIL-15)"

Description: Recombinant Human IL-15 produced in E.Coli is a single, non-glycosylated, polypeptide of 114 amino acids and a molecular mass of 12.8 kDa.  The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.

Biological activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of CTLL-2 was found to be <0.45ng/mL, corresponding to a Specific Activity of 3 x 106 IU/mg.

Amino acid sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS 

rec. human Interleukin-2; rec. Mouse Interleukin-2, rec. Rat Interleukin-2, rec. human Interleukin-7, rec. human Interleukin-15

Specifications:
Purity: >97% (by RP-HPLC, SDS-PAGE)
Sterile Filtered White lyophilized (freeze-dried) powder. The protein was lyophilized from PBS pH7.4.


Applikation / Application:
Einheiten / Units:
Quelle / Source:
Escherichia Coli.


Sicherheits Hinweise / Safety


Klassifizierungen / Classification

eclass-Nr: 32-16-04-90
Documents - Protocols - Downloads :
Here you will find information and further literature. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.


Documents:

Product description
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Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.
Source: NCBI PubMed