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rec. Human Vascular Endothelial Growth Factor (rHuVEGF)

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€252.00*

Weight
Product number: C6036.0010
Delivery time: 3- 8 working days
For detailed information on the delivery date, please contact Genaxxon.

Shipment: not cooled. Stored at -20°C. For laboratory usage only!
Product information "rec. Human Vascular Endothelial Growth Factor (rHuVEGF)"

Description:
Vascular endothelial growth factor is an important signaling protein involved in both vasculogenesis and angiogenesis. As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ). VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy.

The recombinant human VEGF is isolated from E.Coli  as a double, non-glycosylated, polypeptide of 165 amino acids (each dimer) and a total molecular mass of approx. 39kDa.

Amino acid sequence:
APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR.

Biological Activity:
The biological activity was determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 3.7-5.6 ng/mL, corresponding to a Specific Activity of 178,570 to 270,270 IU/mg.

Lyophilized from a concentrated (1mg/mL) solution with no additives.

Specifications:
Purity: >95% (by RP-HPLC, SDS-PAGE).

Biological Activity:
The biological activity was determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 3.7-5.6 ng/mL, corresponding to a Specific Activity of 178,570 to 270,270 IU/mg.


Applikation / Application:
Einheiten / Units:
Quelle / Source:
Escherichia Coli


Sicherheits Hinweise / Safety


Klassifizierungen / Classification

eclass-Nr: 32-16-04-90
Documents - Protocols - Downloads :
Here you will find information and further literature. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.


Documents:

Product description
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Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.
Source: NCBI PubMed