rec. Murine Granulocyte Macrophage Colony Stimulating Factor (rmGM-CSF)

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Weight

5 µg

20 µg

Product number: C6040.0005
Delivery time: 3- 8 working days
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Shipment: not cooled. Stored at -20°C. For laboratory usage only!

Product information "rec. Murine Granulocyte Macrophage Colony Stimulating Factor (rmGM-CSF)"

Recombinant murine GM-CSF produced in E.Coli is a single, non-glycosylated, polypeptide chain of 125 amino acids and a molecular mass of 14,285 Dalton. The ED50 as determined by the dose-dependant stimulation of the proliferation of murine FDC-P1 cell line is <0.2ng/mL, corresponding to a Specific Activity of 5,000,000 IU/mg. GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Synonyms: CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, Molgramostin, Sargramostim.

Synonyms: CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, Molgramostin, Sargramostim.

Biological activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of murine FDC-P1 cell line is <0.2ng/mL, corresponding to a Specific Activity of 5,000,000 IU/mg.

Sequence: The sequence of the first five N-terminal amino acids is Met-Ala-Pro-Thr-Arg.

Specifications:
Purity: > 98.0% (by RP-HPLC)
Less than 1% dimers and aggregates.

Sterile Filtered White lyophilized (freeze-dried) powder. The lyophilized rmGM-CSF is soluble in water and most aqueous buffers above the isoelectric point (pI=5.9).

Applikation / Application:

Einheiten / Units:

Quelle / Source:

Escherichia Coli.

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 32-16-04-90

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Source: NCBI PubMed