rmVEGF - recombinant Vascular Endothelial Growth Factor Mouse

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Weight

1 mg

2 µg

10 µg

Product number: C6393.1000
Delivery time: 3- 8 working days
For detailed information on the delivery date, please contact Genaxxon.

Shipment: not cooled. Stored at -20°C. For laboratory usage only!

Product information "rmVEGF - recombinant Vascular Endothelial Growth Factor Mouse"

Description:
rmVEGF the vascular endothelial growth factor is an important signaling protein involved in both vasculogenesis and angiogenesis. VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells). VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.
Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy.

The recombinant mouse VEGF is isolated from E.Coli as a double, non-glycosylated, polypeptide of 165 amino acids (each dimer) and a total molecular mass of approx. 39kDa.

Amino acid sequence:
MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR.

Biological Activity:
The biological activity is determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-7.0 ng/mL.

The protein was sterile filtered (0.2µm) and lyophilized from a concentrated (1mg/mL) PBS solution, pH7.4.

Specifications:
Assay/Purity: >95.0% (RP-HPLC)

Applikation / Application:

Einheiten / Units:

Quelle / Source:

rec. from E.Coli

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 32-16-04-90

Documents - Protocols - Downloads :

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Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.
Source: NCBI PubMed