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Isoniazid, also known as isonicotinylhydrazide (or INH), is an organic compound that is the first-line medication in prevention and treatment of tuberculosis.
Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in mycobacterium tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH (M6056) > to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall.
Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing. It inhibits the P450 system and hence acts as a source of free radicals.
Synonyms: INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide ; 4-Pyridinecarboxylic acid hydrazide; 4-(Hydrazinocarbonyl)pyridine
Isoniazid is often used together with Rifampicin (M3144) >.
Assay: 99% - 101%
Appearance: White to off-white crystalline powder
MP = 170°C - 173°C
Residue on ignition: 0.1%
Loss on drying: <0.5%
MW = 137.14 g/mol
Sicherheits Hinweise / SafetyH-Sätze: H302, H315
Klassifizierungen / ClassificationEC-Nr: 200-214-6
Dokumente - Protokolle - Downloads
Here you will find information and further literature on Isoniazid. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: firstname.lastname@example.org or phone: +49 731 3608 123.