Amphotericin B Powder

Amphotericin B - chemical structure


Order number: M3108.0050

Shipping: shipped at RT, store at +2°C to +8°C
CAS-Nr: 1397-89-3

Delivery time: 3- 8 working days
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For tissue culture to prevent growth of yeasts and fungi. Amphotericin B is an antifungal... more
Product information "Amphotericin B Powder"

For tissue culture to prevent growth of yeasts and fungi. Amphotericin B is an antifungal and was isolated from Streptomyces nodosus. It is one of the macrocyclic lactones and its action is fungistatic. Amphotericin B binds to sterols (eg. As cholesterol, cholestanol) with a planar structure and disturb thereby the permeability of the cell membrane, which it for ions (K+, Na+, H+) and other low molecular weight substances (eg. As amino acids, sugars, nucleotides ) permeable makes.

The cytotoxic concentration is 30μg/mL and the recommended work concentration at 2.5μg/mL.

Amphotericin B is almost insoluble in water at pH6-7, at pH2 and pH11 soluble with 100µg/mL. In DMSO 30-40mg/mL can be dissolved. Addition of deoxycholate in phosphate buffer improves water solubility.

Genaxxon bioscience offers a broad range of Antibiotics and Antimycotics as powder or solutions.

Fungizone is a registered trademark of E.R. Squibb.

More products around "Amphotericin B Powder"
Specifications: Assay: >80% Activity: min. 750 I.E./mg Solubility: clear, yellow solution... more
 

Technical Data:

Specifications:
Assay: >80%
Activity: min. 750 I.E./mg
Solubility: clear, yellow solution ((10%, DMF/1M HCl 3 : 1)
Solubility: almost unsoluble in water, soluble in DMSO
Amphotericin A: max. 15%
Water: max. 5%
C47H73NO17
MW = 924.08 g/mol

For tissue culture prepare a 2.5µg/mL solution.

Source

Streptomyces ssp.

Sicherheits Hinweise / Safety

H-Sätze: H315, H319, H335
GHS-Symbole: GHS07
R-Sätze: R22-37/38-41
Gefahrstoffkürzel: Xn

Klassifizierungen / Classification

EC-Nr: 215-742-2
CAS-Nr: 1397-89-3
eclass-Nr: 32-16-04-05
Dokumente - Protokolle - Downloads more


Dokumente - Protokolle - Downloads

Here you will find information and further literature on Amphotericin B Powder. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.

 
 
 
Literatur .... more

Referenzen..

Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.

Quelle/Source: NCBI PubMed >

 

PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

 

Romy Walser, John E. Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L. Williams, Muriel Laffargue, Matthias P. Wymann

 

PLoS Biol. 2013 Jun; 11(6): e1001587. Published online 2013 Jun 25. doi: 10.1371/journal.pbio.1001587

 

PMCID: PMC3692425