Amphotericin B Powder
Order number: M3108.0050
Shipping: Shipment: not cooled. Store at +2°C to +8°C. For laboratory usage only!CAS-Nr: 1397-89-3
Delivery time: 3- 8 working days
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For tissue culture to prevent growth of yeasts and fungi. Amphotericin B is an antifungal and was isolated from Streptomyces nodosus. It is one of the macrocyclic lactones and its action is fungistatic. Amphotericin B binds to sterols (eg. As cholesterol, cholestanol) with a planar structure and disturb thereby the permeability of the cell membrane, which it for ions (K+, Na+, H+) and other low molecular weight substances (eg. As amino acids, sugars, nucleotides ) permeable makes.
The cytotoxic concentration is 30μg/mL and the recommended work concentration at 2.5μg/mL.
Amphotericin B is almost insoluble in water at pH6-7, at pH2 and pH11 soluble with 100µg/mL. In DMSO 30-40mg/mL can be dissolved. Addition of deoxycholate in phosphate buffer improves water solubility.
Genaxxon bioscience offers a broad range of Antibiotics and Antimycotics as powder or solutions.
Fungizone is a registered trademark of E.R. Squibb.
Technical Data:
Specifications:
Assay: >80%
Activity: min. 750 I.E./mg
Solubility: clear, yellow solution ((10%, DMF/1M HCl 3 : 1)
Solubility: almost unsoluble in water, soluble in DMSO
Amphotericin A: max. 15%
Water: max. 5%
C47H73NO17
MW = 924.08 g/mol
For tissue culture prepare a 2.5µg/mL solution.
Source
Streptomyces ssp.Sicherheits Hinweise / Safety
H-Sätze: H315, H319, H335GHS-Symbole: GHS07
R-Sätze: R22-37/38-41
Gefahrstoffkürzel: Xn
Klassifizierungen / Classification
EC-Nr: 215-742-2CAS-Nr: 1397-89-3
eclass-Nr: 32-19-90-90
Dokumente - Protokolle - Downloads
Here you will find information and further literature on Amphotericin B Powder. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.
Referenzen..
Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.
PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control
Romy Walser, John E. Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L. Williams, Muriel Laffargue, Matthias P. Wymann
PLoS Biol. 2013 Jun; 11(6): e1001587. Published online 2013 Jun 25. doi: 10.1371/journal.pbio.1001587
PMCID: PMC3692425
