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Apramycin is produced from Streptomyces tenebrarius. It is used to study antibiotic resistance as well as protein synthesis translocation-step inhibition in bacteria and prokaryotes. Apramycin is an aminoglycoside antibioticum and has a bactericidal action against many gram-negative bacteria. Apramycin inhibits protein synthesis by blocking translocation. It is also able to bind to the eukaryotic decoding site. At low concentrations it inhibits elongation and induces misreading of mRNA during protein synthesis.
Apramycin is a structurally unique antibioticum that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. Apramycin can only be acetylated by AAC-(3)IV and as a consequence of this enzymatic modification, the antibioticum is unable to enter the cell to bind to its ribosomal target.
Apramycin (also Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. It is used in pigs, sheep, cows, chicken and rabbits.
Assay: Apramycin: ≥550μg/mg (anhydrous basis)
Loss on drying: <10%
Residue on ignition: <1%
MW: 637.64 g/mol
Solubility: Soluble in water.
Sicherheits Hinweise / SafetyH-Sätze: H315, H319, H360
GHS-Symbole: GHS07, GHS08
Klassifizierungen / ClassificationEC-Nr: 265-890-7
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