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Doxycycline belongs to the generation of the newer tetracycline derivatives and is active against grampositive and gramnegative germs. Accordingly, it shows the same mechanism of action, i.e. an inhibition of the protein synthesis at the ribosomes. In the TET expression system, Doxycycline may replace Tetracycline >. The working concentration for the inactivation of tTA in double-stable cell lines is 1 - 20 ng/ml in the culture medium. Doxycycline is a broad spectrum inhibitor of metalloproteinases in vivo.
Solubility and stability: The crystalline substance of Doxycycline is stable. The hyclate salt of Doxycycline is watersoluble. Stability of Doxycylcine in aqueous solutions depends on the pH value: an acidic pH value increases stability (more than 30 days at ambient temperature without loss of activity at pH 1 - 2,5). At pH 7 and ambient temperature, it is stable for more than 1 week. Doxycycline forms complexes with calcium ions, which leads to an inactivation of the antibiotic. Avoid high calcium concentrations in your assay.
Solubility (1%, H2O): clear, chartreuse
Ethanol: max. 7%
Water: max. 5%
C22H25ClN2O8 x 1/2 H2O x 1/2 C2H60
Sicherheits Hinweise / SafetyH-Sätze: H302, H315, H319, H335
Klassifizierungen / ClassificationCAS-Nr: 24390-14-5
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Here you will find information and further literature on Doxycycline Hyclat. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: email@example.com or phone: +49 731 3608 123.