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Phleomycin belongs to the bleomycin antibiotic family exhibiting in vivo activity against bacteria, eukaryotic microorganisms, plants and animal cells. Phleomycin undergoes irresversible denaturation at pH4.0 and below. It is a mixture of different Bleomycin salts. Bleomycin itselves finds use as a cytostatic drug in chemotherapy because it causes double-strand breaks in the DNA.
It binds and intercalates DNA thus destroying the integrity of the double helix. Phleomycin is active against most bacteria, filamentous fungi, yeast, plant and animal cells.
Use of phleomycin is recommended for cells poorly sensitive to Zeocin™, i.e. filamentous fungi and some yeasts.
Phleomycin resistance is conferred by the Sh ble gene from Streptoalloteichus hindustanus which encodes a protein that binds to phleomycin, inhibiting its DNA cleavage activity.
Typically, phleomycin is used at a concentration of 10µg/µL (yeasts) and 25-150,µg/µL (filamentous fungi).
Assay: min. 90% (HPLC)
Appearance: blue, hygroscopic powder
Absorbance: 0.2 - 0.3 (0.06% at 244nm)
MW = 1525 g/mol
C55H85O21N20S2Cu x HCl
SourceFrom Streptomyces verticullus mutant
Sicherheits Hinweise / SafetyH-Sätze: H302
Klassifizierungen / ClassificationCAS-Nr: 11006-33-0
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Here you will find information and further literature on Phleomycin Powder - Bleomycin. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: firstname.lastname@example.org or phone: +49 731 3608 123.
Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
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Laura Knuppertz, Andrea Hamann, Francesco Pampaloni, Ernst Stelzer, Heinz D Osiewacz
Autophagy. 2014 May; 10(5): 822–834. Published online 2014 Feb 27. doi: 10.4161/auto.28148