Phleomycin Powder - Bleomycin

Phleomycin


Order number: M3429.0250

Shipping: shipped at RT, stored at +2°C to +8°C
CAS-Nr: 11006-33-0

Delivery time: 3- 8 working days
For detailed information on the delivery date, please contact Genaxxon.

€544.80 *

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Phleomycin belongs to the bleomycin antibiotic family exhibiting in vivo activity against... more
Product information "Phleomycin Powder - Bleomycin"

Phleomycin belongs to the bleomycin antibiotic family exhibiting in vivo activity against bacteria, eukaryotic microorganisms, plants and animal cells. Phleomycin undergoes irresversible denaturation at pH4.0 and below. It is a mixture of different Bleomycin salts. Bleomycin itselves finds use as a cytostatic drug in chemotherapy because it causes double-strand breaks in the DNA.

It binds and intercalates DNA thus destroying the integrity of the double helix. Phleomycin is active against most bacteria, filamentous fungi, yeast, plant and animal cells.

Use of phleomycin is recommended for cells poorly sensitive to Zeocin™, i.e. filamentous fungi and some yeasts.

Phleomycin resistance is conferred by the Sh ble gene from Streptoalloteichus hindustanus which encodes a protein that binds to phleomycin, inhibiting its DNA cleavage activity.

Typically, phleomycin is used at a concentration of 10µg/µL (yeasts) and 25-150,µg/µL (filamentous fungi).

More products around "Phleomycin Powder - Bleomycin"
Specifications: Assay: min. 90% (HPLC) Appearance: blue, hygroscopic powder Absorbance: 0.2 -... more
 

Technical Data:

Specifications:
Assay: min. 90% (HPLC)
Appearance: blue, hygroscopic powder
Absorbance: 0.2 - 0.3 (0.06% at 244nm)
MW = 1525 g/mol
C55H85O21N20S2Cu x HCl

Source

From Streptomyces verticullus mutant

Sicherheits Hinweise / Safety

H-Sätze: H302
GHS-Symbole: GHS07

Klassifizierungen / Classification

CAS-Nr: 11006-33-0
eclass-Nr: 32-16-04-05
Dokumente - Protokolle - Downloads more

Dokumente - Protokolle - Downloads

Here you will find information and further literature on Phleomycin Powder - Bleomycin. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.

 
 
 
Literatur .... more

Referenzen..

Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.

Quelle/Source: NCBI PubMed >

 

Identification of autophagy as a longevity-assurance mechanism in the aging model Podospora anserina

 

Laura Knuppertz, Andrea Hamann, Francesco Pampaloni, Ernst Stelzer, Heinz D Osiewacz

 

Autophagy. 2014 May; 10(5): 822–834. Published online 2014 Feb 27. doi: 10.4161/auto.28148

 

PMCID: PMC5119060

 

 
 
 
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