E-64 cystein protease inhibitor

E-64 - chemical structure


Order number: S5219.0005

Shipping: shipped at RT, stored at -20°C, keep tightly sealed. Bottled under Argon.
CAS-Nr: 66701-25-5

Delivery time: 3- 8 working days
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€144.47 *

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E-64 is an irreversible inhibitor of different cysteine proteases (papain, bromelain, ficin,... more
Product information "E-64 cystein protease inhibitor"

E-64 is an irreversible inhibitor of different cysteine proteases (papain, bromelain, ficin, cathepsin B, H and L, tumor-cathepsin, calpain, V-CATH from Autographa californica M nucleopolyhedro virus (AcMNPV) and Streptococcus-protease). All enzymes are completely inhibited by a concentration of 10 - 30 μM within 30 minutes.

E-64 and other protease inhibitors (e. g. diisopropylfluorophosphate and PMSF) are able to inhibit the programmed cell death, that is induced by activation of the T cell receptor in different cell lines of the immune system, not by blocking the signal transduction. The effect of dexamethason, which induces apoptosis as an antagonist of the T cell receptor, is enhanced.

If proteins are expressed in the baculo virus system with a functional v-cath gene, very often a proteolytic activity can be observed. This reduces the quality of the expressed protein significantly. The addition of E-64 to all reaction steps avoids the degradation almost completely.

Stability:
E-64 is stable against reducing agents. Stock solutions have concentrations between 1mM and 10mM in DMSO or 50% ethanol and are stable for several days, if stored at +4°C. Aliquots may be stored at -20°C for approx. one month.

Synonyme: trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butan; L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatin; N-(trans-Epoxysuccinyl)-L-leucin-4-guanidinobutylamid

You will find further protease inhibitors here: Inhibitors >: Pepstatin A >, AEBSF >, Leupeptin >, TLCK >, PMSF >, Bestatine > or Diisopropylphosphorofluoridat (DFP) >.

More products around "E-64 cystein protease inhibitor"
Specifications: Assay: min. 99.0% (TLC) Solubility (2% in water): clear, coulorless solution... more
 

Technical Data:

Specifications:
Assay: min. 99.0% (TLC)
Solubility (2% in water): clear, coulorless solution
a20°C/D (1% in 0.1 HCl): +23° - +26°
C15H27N5O5
MW = 357.40 g/mol

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

CAS-Nr: 66701-25-5
eclass-Nr: 32-16-04-05
Dokumente - Protokolle - Downloads more

Dokumente - Protokolle - Downloads

Here you will find information and further literature on E-64 cystein protease inhibitor. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.