L-Methionine sulfoximine (MSX)

L-Methionine sulfoximine


Order number: S2272.0001

Shipping: shipped at RT, stored at +2°C to +8°C
CAS-Nr: 15985-39-4

Delivery time: 3- 8 working days
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€278.42 *

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L-Methionine sulfoximine is a potent inhibitor of glutamine sythetase activity, that is widely... more
Product information "L-Methionine sulfoximine (MSX)"

L-Methionine sulfoximine is a potent inhibitor of glutamine sythetase activity, that is widely used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines. The growing demand for high yield cell banks for production of recombinant proteins for therapeutics has resulted in two major systems for selection of stable and active clones, Methotrexate selection of dihydrofolate reductase (DHFR) overexpressing cells and MSX selection of glutamine synthetase overexpressing cells. Cells are grown in the absence of glutamine in the media and inhibition of the endogenous activity of glutamine synthease results in cell death for cells lacking overexpression. The MSX-glutamine synthase selection mechanism provides benefits over that of the Methotrexate-DHFR system in that it typically requires a single amplification step and results in significant reduction of time to produce high stability, highly amplified clones.

Methionine sulfoximine (MSX) increases ornithine decarboxylase activity, decreases the survival rate in a model of transient cerebral ischemia, and inhibits glutamine synthetase activity.

You will find further protease inhibitors here: Inhibitors >: Pepstatin A >, AEBSF >, Leupeptin >, TLCK >, PMSF >, Bestatine > or Diisopropylphosphorofluoridat (DFP) >.

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Our comment on "L-Methionine sulfoximine (MSX)"
Methionine sulfoximine (MSX) increases ornithine decarboxylase activity, decreases the survival rate in a model of transient cerebral ischemia, and inhibits glutamine synthetase activity.
Specifications: Assay: min. 95% (TLC) Appearance: white to off-white powder Solubility... more
 

Technical Data:

Specifications:
Assay: min. 95% (TLC)
Appearance: white to off-white powder
Solubility (50mg/mL in H2O): clear to slightly hazy
a20°C/D (1% in 0.1 HCl): +10.8° - +14°
C5H12N2O3S
MW = 180.23 g/mol

application:

selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines

Source

synthetic

Sicherheits Hinweise / Safety

H-Sätze: H315, H319, H335
GHS-Symbole: GHS07

Klassifizierungen / Classification

CAS-Nr: 15985-39-4
eclass-Nr: 32-16-04-05
Dokumente - Protokolle - Downloads more

Dokumente - Protokolle - Downloads

Here you will find information and further literature on L-Methionine sulfoximine (MSX). For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.