2',3'- Dideoxyadenosine-5'-O-triphosphate (ddATP)

ddATP


Order number: M3443.0005

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CAS-Nr: 132619-65-9

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2',3'-Dideoxyadenosine-5'-O-triphosphate (ddATP) sodium salt of purity >95% HPLC. For other salt... more
Product information "2',3'- Dideoxyadenosine-5'-O-triphosphate (ddATP)"

2',3'-Dideoxyadenosine-5'-O-triphosphate (ddATP) sodium salt of purity >95% HPLC. For other salt forms or a guaranteed higher purity please inquire.

2',3'-Dideoxyadenosine-5'-Triphosphate (ddATP) is a modified nucleoside triphosphate, where the 2' and 3' hydroxyl groups are absent, resulting in chain termination while PCR. The inability of polymerases to extend from a dideoxy nucleotide causes the chain termination and is widely useful in antiviral research and in a variety of biotechnology applications. ddATP is used in cycle sequencing, enzyme mechanistic studies and for producing RNA and DNA sequences that cannot be extended by polymerases or joined by DNA ligases.

Another notable application that utilizes a primer terminated on the 3′ end with a dideoxy modification is pyrophosphorolysis-activated polymerization (PAP). This technique is valuable for the detection of rare mutations.

Reference: Sanger et al., Proc. Natl. Acad. Sci. USA, 74, 5463 - 5467 (1977).

ddATP is an analogue of cyditine triphosphate (ATP) where both ribose hydroxy groups have been removed and replaced by hydrogen.

More products around "2',3'- Dideoxyadenosine-5'-O-triphosphate (ddATP)"
Specifications: Purity: min. 95% (HPLC) 10mM solution λmax = 259 nm; ε = 15000.01 λ x mmol -1... more
 

Technical Data:

Specifications:
Purity: min. 95% (HPLC)
10mM solution
λmax = 259 nm; ε = 15000.01 λ x mmol-1 x cm-1
C10H16N5O11P3
MW = 475.2 g/mol (free acid)
Non-sterile, pH7.6

500µL of 10mM sodium salt solution

Source

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

CAS-Nr: 132619-65-9
eclass-Nr: 32-16-05-02
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Dokumente - Protokolle - Downloads

Here you will find information and further literature on 2',3'- Dideoxyadenosine-5'-O-triphosphate (ddATP). For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.