Amyloid-beta (16-20) KLVFF inhibitor peptide of Amyloid-beta

Amyloid-beta (16-20) KLVFF inhibitor peptide of Amyloid-beta


Order number: P2255.9505

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[beta]-Amyloid (16-20) - KLVFF (peptide sequence: KLVFF) ist used as a test peptide for the... more
Product information "Amyloid-beta (16-20) KLVFF inhibitor peptide of Amyloid-beta"

[beta]-Amyloid (16-20) - KLVFF (peptide sequence: KLVFF) ist used as a test peptide for the hydrophilic part of the complete Amyloid beta 1-40 peptide.

The KLVFF peptide is one of several inhibitors of amyloid-beta aggregation that have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were identified by phage display approaches. An overview about peptides that target amyloid-beta is described by Stains et al. (2007) ChemMedChem 2, 1674-1692.

The characteristic of Alzheimer disease is the accumulation of amyloid plaques in the brain. The major components of these plaques are 39-42 residue-long amyloid-ß-peptides, which form insoluble fibrils via self-assembly. The amyloid-ß-peptides are fragments of the broadly distributed, membrane-bound amyloid precursor protein APP, encoded on chromosome 21. They are formed from the proteolytic cleavage of APP by ß- and g-secretases. Cleavage occurs after residue 40 or after residue 42. Even slightly increased amounts of amyloid-ß1-42 are described to be sufficient to cause Alzheimer's disease.

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P2248 - Amyloid-beta (1-40) rat - DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV - HCl salt peptide >
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More products around "Amyloid-beta (16-20) KLVFF inhibitor peptide of Amyloid-beta"
Specifications: Purity: >95% (HPLC) Sequence: KLVFF Appearance: lyophilized, white... more
 

Technical Data:

Specifications:
Purity: >95% (HPLC)
Sequence: KLVFF
Appearance: lyophilized, white powder

application:

study of Alzheimer desease Fibrilization, fibrillogenesis studies

Source

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads more


Dokumente - Protokolle - Downloads

Here you will find information and further literature on Amyloid-beta (16-20) KLVFF inhibitor peptide of Amyloid-beta. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.